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Owners with dogs testing as Carriers (CP1 N/A) should understand that their dogs can produce puppies with cleft palate if bred to other carriers. In addition, all NSDTR breeders should understand that this test is specific for the mutation identified to cause the CP1 form of cleft palate. At the time that this test was released, approximately 15% of Tollers were identified as carriers of CP1 N/A; however, the number of carriers can change with each generation. As of March 2012, we have received 29 samples from North American NSDTR puppies with cleft palate, 18 of which had two mutant (CP1 A/A) copies of CP1.
If two carriers of CP1 are bred to each other 25% of the puppies will have cleft palate caused by CP1. If a carrier is bred to a normal dog then no CP1 puppies will be produced.
We recommend that breeders take into consideration the CP1 test results as they plan their breeding programs; however, they should not over-emphasize the test results. Instead, the test result should be one factor among many in a balanced breeding program.